Method of preventing or reducing the risk of infection by bacterial pathogens utilizing simple and conjugated dextrans
AssigneeThe University of British Columbia
InventorsDavid P. Speert, Thomas C. Usher
Life of this patent
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Abstract
Methods for reducing the risk of or preventing infections by bacterial pathogens in vivo. In particular, a method for reducing the risk of P. aeruginosa infection in vivo in compromised hosts such as cystic fibrosis patients. The methods involve the use of dextran or dextran sulphate as the active ingredient.
Claims17
A method for reducing the risk of respiratory system infection by bacterial pathogens which comprises administering to a patient in need of such treatment a pharmaceutical composition comprising an effective amount of dextran in admixture with a pharmaceutically acceptable diluent or carrier.
A method for reducing adhesion of bacterial pathogens to buccal or respiratory epithelial cells in vivo which comprises administering to a patient in need of such treatment a pharmaceutical composition comprising an effective amount of dextran in admixture with a pharmaceutically acceptable diluent or carrier.
A method for reducing the risk of respiratory tract infection by Pseudomonas aeruginosa in a patient having cystic fibrosis which comprises administering to said patient a pharmaceutical composition comprising an effective amount of dextran in admixture with a pharmaceutically acceptable diluent or carrier.
Dependencies are inferred from the claim text.