Senna dosage form
AssigneeThe Procter & Gamble Company
InventorKenneth G. Mandel
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Abstract
This invention relates to a pharmaceutical laxative composition in unit dosage form, for peroral administration of sennosides to a human or other animal subject, comprising a safe and effective amount of sennosides in a rapidly dissolving matrix; and a proximal colonic delivery carrier which effects release of said sennosides substantially near the junction between the small intestine and the colon or within the colon of said subject. This invention also involves methods for providing laxation for humans and other animals in need thereof by peroral administration of such compositions.
Claims12
A pharmaceutical laxative composition in unit dosage form, for peroral administration of sennosides to a human or other animal subject, comprising:
- (a) from about 3 mg to 25 mg of sennosides contained in a rapidly dissolving matrix;
- and
- (b) a proximal colonic delivery carrier which effects release of said sennosides near the junction between the small intestine and the colon or within the colon of said subject, wherein the proximal colonic delivery carrier is selected from the group consisting of pH sensitive enteric material. S, pulse capsules and time dependent-release coating materials, and wherein the sennoside matrix completely dissolves within about 1 to 20 minutes after the proximal colonic delivery carrier begins dissolving.
Dependencies are inferred from the claim text.