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US 5,514,662 AGranted
Use of amphotericin B derivatives as protease inhibitors
AssigneeLaboratoires Mayoly Spindler (S.A.R.L.)
InventorMichel Seman
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Abstract
The invention is directed toward the use of amphotericin B and derivatives thereof as inhibitors of serine-proteases and for applying these inhibitors for the production of medicinal products intended for the treatment of infection by the human immunodeficiency virus (HIV).
Claims3
A method for inhibiting the multiplication cycle of a vital agent in host cells wherein said multiplication cycle entails a serine protease comprising:
- contacting said viral agent and host cells with an effective serine protease inhibiting amount of a compound of formula (I) ##STR3## where R.sub.1 represents a polyene macrolide of amphotericin B, R.sub.2 represents a hydrogen atom or a methyl group, and R.sub.3 represents a methyl, ethyl, propyl or phenyl group.
Dependencies are inferred from the claim text.