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AssigneeNEOSE Pharmaceuticals, Inc.
InventorsDavid A. Zopf, Paul M. Simon, Stephen Roth, Edward J. McGuire, Dennis H. Langer
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A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula I (NeuAc-.alpha.(2-3)-Gal-.beta.(1)-(--X--).sub.m -(--Y--).sub.n -).sub.p -Z wherein X=a chemical bond or a group capable of linking the galactose to either the linking group Y or the multivalent support Z; wherein the C.sub.1 glycosidic oxygen of galactose may be replaced by N, S or C; Y=a linking group; Z=a multivalent support; m=0 or 1; n=0 or 1; and p=an integer of 2-1,000 is described. Also described is a method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of Formula II NeuAc-.alpha.(2-3)-Gal-.beta.(1)-A wherein A=a group capable of bonding to the galactose; wherein the C.sub.1 glycosidic oxygen of galactose may be replaced by N, S or C.
A method of treating or preventing an ulcer in the stomach or duodenum of a mammalian patient in need thereof, comprising administering to the stomach or duodenum of said mammalian patient, an effective amount to produce an effective stomach concentration of oligosaccharide of from 1 .mu.g to 10,000 mg/ml per dose, of a composition comprising an oligosaccharide of Formula I
A method of treating or preventing an ulcer in the stomach or duodenum of a mammalian patient in need thereof, comprising administering to the stomach or duodenum of said mammalian patient, an effective amount to produce an effective stomach concentration of oligosaccharide of from 1 .mu.g to 10,000 mg/ml per dose, of a composition comprising an oligosaccharide of Formula II
A method of inhibiting an H. pylori infection or reinfection in the stomach or duodenum of a mammalian patient in need thereof, comprising administering to the stomach or duodenum of said mammalian patient, an effective amount to produce an effective stomach concentration of oligosaccharide of from 1 .mu.g to 10,000 mg/ml per dose, of a composition comprising an oligosaccharide of Formula I
A method of inhibiting an H. pylori infection or reinfection in the stomach or duodenum of a mammalian patient in need thereof, comprising administering to the stomach or duodenum of said mammalian patient, an effective amount to produce an effective stomach concentration of oligosaccharide of from 1 .mu.g to 10,000 mg/ml per dose, of a composition comprising an oligosaccharide of Formula II
Dependencies are inferred from the claim text.