Oligosaccharides for inhibiting the mitosis of astrocytes and tumoral cells of the nervous system, and methods for obtaining them

Abstract

A method for obtaining oligosaccharides starts with allylation of position (3') of .beta.-lactosides followed by controlled benzylation, which leads to perbenzylated and partially benzylated compounds. The latter are glycosylated at position 3, not benzylated, with a donor of .varies.-fucopyranosyl to yield protected trisaccharides. These and perbenzylated .beta.-Lactosides are deallylated and, later, are glycosylated with 2-azido-2-deoxy-.varies.-D-galactopyranosyl to yield protected tetrasaccharides and trisaccharides, respectively. The debenzylation of said products accompanied by the reduction of the azido group and simultaneous acetylation of the amino group produces intermediary products which, by O-deacetylation, leads respectively to the final tetrasaccharides and trisaccharides. The resulting oligosaccharides produce inhibition of mitosis in astrocytes and tumoral cells of the nervous system and, for this reason, can be used for controlling glial scar and for treatment of tumors of the nervous system.

Dependencies are inferred from the claim text.