Method of blocking the SEC receptor
AssigneeWashington University
InventorDavid H. Perlmutter
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Abstract
A method is disclosed for blocking the SEC receptor and also inhibiting the neurotoxic effects of amyloid-.beta. protein by treating SEC receptor-bearing cells with a synthetic inhibitor peptide, e.g. peptide PB145.
Claims8
A method of blocking the SEC receptor which comprises subjecting SEC receptor-bearing cells to an inhibitorily effective amount of a peptide selected from the group consisting of PB145, PB96 and PB446.
A method of inhibiting amyloid-.beta. protein neurotoxicity which comprises subjecting SEC receptor-bearing cells to an inhibitorily effective amount of a peptide selected from the group consisting of PB145, PB96 and PB446.
A method for the treatment of Alzheimer's disease comprising administering to a host manifesting said disease an effective amount of a peptide selected from the group consisting of PB145, PB96 and PB446 for inhibiting amyloid-.beta. neurotoxicity in said host.
Dependencies are inferred from the claim text.