Therapy of respiratory tract diseases using basic fibroblast growth factor
AssigneeKaken Pharmaceutical Co., Ltd.
InventorsMitsuru Watanuki, Tsutomu Nakamura, Masaru Ogawa
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Abstract
The present invention relates to a preparation for the therapy of respiratory tract diseases which contains a basic fibroblast growth factor and/or a homologue thereof as an active ingredient, a preparation for the therapy of respiratory tract diseases which contains a human basic fibroblast growth factor and/or a homologue thereof, produced by microorganisms or cultured cells prepared by genetic recombination, as an active ingredient, and a method for the therapy of respiratory tract diseases by administering any one of these preparations.
Claims3
A method for the treatment of asthma or bronchitis comprising administering to the diseased part of the respiratory tract an effective amount of at least one member selected from the group consisting of:
- basic fibroblast growth factor (bFGF) consisting of 146 amino acids, 157 amino acids, 155 amino acids, 147 amino acids, wherein the 147 amino acid form includes an N-terminal methionine, and a bFGF consisting of 146 amino acids wherein Cys.sup.69 and Cys.sup.87 are replaced by serine, to a warm-blooded animal in need thereof and wherein the bFGF is human or bovine.
Dependencies are inferred from the claim text.