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AssigneesNew York Blood Center, Inc., JCR Pharmaceuticals Co., Ltd., Santen Pharmaceutical Co., Ltd.
InventorsBernard Horowitz, Richard W. Shulman, Adrianne J. Setton, Toyohiko Nishimura, Yoichi Kawashima
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A stable and soluble multi-dose ophthalmic solution is disclosed. The solution contains fibronectin, an amino acid, a sugar, and a lower alkyl p-hydroxybenzoate. A method treatment of ophthalmic wounds employing the ophthalmic solution, a process for preparing fibronectin for ophthalmic use, a method of lyophilizing an aqueous solution of fibronectin free of albumin, a method for inhibiting bacterial growth in an ophthalmic solution while preserving the cellular adhesion and wound healing activities of fibronectin, and a method of treatment of ophthalmic wounds administering a wound-healing accelerator solution are also disclosed.
A method of treatment of ophthalmic wounds comprising administering to the wound a wound healing accelerator solution disposed in a multi-use container, wherein said solution comprises a wound healing accelerator, wherein the wound healing accelerator is fibronectin, epithelial growth factor, or fibroblast growth factor, and a lower alkyl p-hydroxybenzoate preservative, and said wound healing accelerator solution is free of albumin.
An ophthalmic solution for application to ophthalmic wounds comprising a wound healing accelerator and a lower alkyl p-hydroxybenzoate preservative, wherein the wound healing accelerator is fibronectin, epithelial growth factor, or fibroblast growth factor, said ophthalmic solution being free of albumin.
A method for inhibiting bacterial growth in an ophthalmic solution comprising a wound healing accelerator wherein the wound healing accelerator is fibronectin, epithelial growth factor, or fibroblast growth factor, and said ophthalmic solution is free of albumin, said method comprising adding to said ophthalmic solution a lower alkyl p-hydroxybenzoate preservative in an amount sufficient to inhibit bacterial growth in said ophthalmic solution, while preserving the wound healing properties of the wound healing accelerator.
Dependencies are inferred from the claim text.