Insulin analogs modified at position 29 of the B chain
OwnerRonald E. Chance, Richard D. DiMarchi +2inventors
InventorsRonald E. Chance, Richard D. DiMarchi, Bruce H. Frank, James E. Shields
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Abstract
Analogs of human insulin modified at position 29 of the B chain thereof and, optionally, at other positions, have modified physico-chemical and pharmacokinetic properties and are useful in the treatment of hyperglycemia.
Claims81
An insulin analog of the formula ##STR11## or a pharmaceutically acceptable salt thereof, wherein A.sub.21 is Asn, or Ala;
- B.sub.1 is Phe, or is absent;
- B.sub.2 is Val, or is absent;
- B.sub.10 is His, or Asp;
- B.sub.28 is any amino acid;
- B.sub.29 is L-Pro, D-Pro, L-hydroxyproline, D-hydroxyproline;
- and,
- B.sub.30 is Thr, Ala, or is absent.
An insulin analog of the formula ##STR12##
A method of treating hyperglycemia which comprises administering, to a patient in need thereof, an effective amount of an insulin analog of the formula ##STR13##
A pharmaceutical composition which comprises an insulin analog of the formula ##STR14## in combination with a pharmaceutically acceptable carrier, diluent, or excipient.
Dependencies are inferred from the claim text.