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US 5,514,598 AGranted
Prenatal detection of meconium
OwnerMichael Doodyinventor
Life of this patent
Estimating the term…
Abstract
Meconium State Pregnancy is diagnosed by analysis of prenatal maternal fluids for the presence of specific meconium antigens, including a specific meconium protein antigen of approximately 14 KD.
Claims10
A method for detecting prenatal meconium excretion by a fetus comprising the steps of:
- chromatographically separating proteins in a sample obtained from maternal prenatal fluid or amniotic fluid;
- analyzing the separated proteins for the presence of a meconium antigen of approximately 14 KD;
- and
- correlating the presence of the meconium antigen with excretion of meconium by the fetus.
1 more element
A method for determining the presence of meconium in a test sample comprising the steps of:
- reacting a sample suspected of containing meconium with an anti-meconium antibody, which antibody specifically binds a meconium antigen of approximately 14 KD, whereby meconium antigen present in the sample forms an antigen-antibody complex with the anti-meconium antibody;
- detecting antibody-antigen complex with a marker system;
- and
- correlating the presence of the antigen-antibody complex with the presence of meconium in the sample.
1 more element
A method for detecting prenatal meconium excretion by a fetus comprising:
- immobilizing proteins of a maternal prenatal fluid or amniotic fluid sample on a test surface;
- reacting said immobilized proteins with an anti-meconium antibody which antibody specifically binds a meconium antigen of approximately 14 KD to form an antigen-antibody complex;
- analyzing the test surface for the presence of antigen antibody complexes;
- and
- correlating the presence of antigen-antibody complexes with the excretion of meconium by the fetus.
2 more elements
An anti-meconium antibody which specifically binds a meconium antigen of approximately 14 KD.
A diagnostic kit useful in screening prenatal urine for the presence of meconium, the kit comprising:
- an anti-meconium antibody which antibody specifically binds a meconium antigen of approximately 14 KD to form an antigen-antibody complex;
- and
- a marker system for determining the presence of the antigen-antibody complex.
Dependencies are inferred from the claim text.