US 5,514,577 A · Oligonucleotide therapies for modulating the effects of herpes viruses

Abstract

Compositions and methods are provided for the treatment and diagnosis of herpesvirus infections. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with RNA or DNA deriving from a herpesvirus gene corresponding to one of the open reading frames UL5, UL8, UL9, UL20, UL27, UL29, UL30, UL42, UL52 and IE175 of herpes simplex virus type 1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a translation initiation site, a coding region or a 5'-untranslated region. Methods of treating animals suspected of being infected with herpesvirus comprising contacting the animal with an oligonucleotide of the invention are disclosed. Methods for treatment of infections caused by herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, human herpes virus 6, Epstein Barr virus or varicella zoster virus are disclosed.

Claims2

Dependent claims

An oligonucleotide wherein the nucleotide sequence is SEQ ID NO:

1, SEQ ID NO:
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55, SEQ ID NO:
56 or SEQ ID NO:
57.

45 more elements

Dependencies are inferred from the claim text.

Oligonucleotide therapies for modulating the effects of herpes viruses

Life of this patent

Oligonucleotide therapies for modulating the effects of herpes viruses

Life of this patent

Abstract

Claims2