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US 5,514,571 AGranted
Cyclin D1 negative regulatory activity
AssigneeUniversity Technologies International Inc.
InventorKarl T. Riabowol
Life of this patent
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Abstract
Use of cyclin D1 as a negative regulator of cell proliferation is disclosed. Overexpression of cyclin D1 blocks cell growth, while blocking cyclin D1 expression promotes cell proliferation.
Claims8
A method for increasing proliferation of mammalian cells in vitro comprising:
- a) selecting said mammalian cells whose proliferation is to be increased;
- and
- b) decreasing the expression of cyclin D1 in said mammalian cells wherein decreasing cyclin D1 expression causes said increased cell proliferation.
A method for decreasing proliferation of mammalian cells in vitro comprising:
- a) selecting said mammalian cells whose proliferation is to be decreased;
- and
- b) increasing the expression of cyclin D1 in said mammalian cells wherein increasing cyclin D1 expression causes said decreased cell proliferation.
Dependencies are inferred from the claim text.