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US 5,514,565 AGranted
Enzymatically-produced dimeric IL-2 and a nerve-derived transglutaminase enzyme for its preparation
AssigneeYeda Research and Development Co. Ltd.
InventorsMichael Schwartz, Shoshana Eitan
Life of this patent
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Abstract
The invention provides a new nerve-derived transglutaminase enzyme that converts immune-derived IL-2 to dimeric IL-2 having oligodendrocyte cytotoxic activity. Both the nerve-derived transglutaminase and the dimeric mammalian, e.g. human, IL-2, are for use as active ingredients in pharmaceutical compositions for inducing and facilitating regeneration of injured nerves of the central nervous system in mammals.
Claims4
A method for producing dimeric IL-2 having oligodendrocyte cytotoxic activity comprising
- incubating monomeric IL-2 with a transglutaminase enzyme obtainable from injured fish optic nerve which dimerizes monomeric IL-2 into dimeric IL-2 having said activity
- whereby said monomeric IL-2 is dimerized to form dimeric IL-2 having said activity, and
- recovering said dimeric IL-2.
Dependencies are inferred from the claim text.