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US 5,514,552 AGranted
Hybrid neuronal cell lines compositions and methods
AssigneeArch Development Corporation
InventorsMarsha R. Rosner, Eva M. Eves, Bruce H. Wainer
Life of this patent
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Abstract
The present invention provides a process of producing an immortalized hybrid neuronal cell comprising the steps of transducing a primary embryonic brain cell from a specific brain region with a temperature-sensitive oncogene to produce a transductant cell, and fusing the transductant cell with a mature primary neuron from the same brain region to produce the hybrid cell. Hybrid cells produced by such a process are also provided.
Claims8
A process of preparing a hybrid neuronal cell from a specific brain region, said process comprising the steps of:
- a) transducing a primary embryonic brain cell from said brain region with a temperature-sensitive oncogene to produce a transductant cell;
- and
- b) fusing said transductant cell with a mature primary neuron from said brain region to produce said hybrid cell.
Dependencies are inferred from the claim text.