Process for the preparation of tablets of derivatives of cephalosporanic acid by direct compression

A dry process for the preparation of tablets of 7-acylaminocephalosporanic acid comprising carrying out a direct compression of a mixture comprising said acid and at least one pharmaceutical excipient, said acid comprising at least about 25% by weight of said mixture and wherein the 7-acylaminocephalosporanic acid has a particle size distribution such that:

• fewer than 5% of particles have a diameter greater than 250.mu.,
• between 55 and 95% of the particles have a diameter of between 250 and 90.mu.N, and
• between 5 and 40% of the particles have a diameter smaller than 90.mu..