Biodegradable hydrogel copolymer as drug delivery matrix
AssigneeSam Yang Co., Ltd.
InventorsSoo S. Song, Ho H. Kim, Yil W. Yi
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Abstract
This invention concerns the thermoplastic, biodegradable hydrogel copolymer which is easily degraded and excreted in human body by the hydrolysis of intramolecular ester and amide bond. The structure of present copolymer comprises i) hydrophilic and swellable soft domain consisting of polyethyleneoxide (PEO), and ii) hydrophobic, biodegradable, crystallizable and non-swellable hard domain consisting of polylactide (PLA), polyglycolide (PGA), polylactideglycolide (PLGA) and polycaprolactone (PCL).
Claims5
A process for preparing a thermoplastic, biodegradable hydrogel multi-block copolymer for use as a drug delivery matrix comprising the steps of:
- i) preparing a hydrophilic block having a biodegradable linkage using a hydrophilic polymer selected from the group consisting of polyethyleneoxide having a number average molecular weight from 2,000 to 10,000 and a copolymer of polyethyleneoxide and polypropyleneoxide;
- ii) introducing hydroxyl groups to both ends of said hydrophilic block;
- iii) adding and polymerizing one or more monomers to form a hydrophobic block, said one or more monomers selected from the group consisting lactide, glycolide and caprolactone;
- and
- iv) adding and anion polymerizing monomers of ethyleneoxide.
Dependencies are inferred from the claim text.