High dosage topical forms of collagenase
AssigneeAdvance Biofactures of Curacao, N.V.
InventorsHarold Stern, David Yee
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Abstract
This invention provides pharmaceutical compositions for topical application containing high concentrations of the enzyme collagenase in non-aqueous excipients. The invention also provides a particular excipient, dextran, which is especially useful for admixture with collagenase and which can also be used to advantage with other pharmaceutically active materials.
Claims30
A method of treating a wound or other condition of the body subject to topical treatment which comprises applying thereto a composition consisting essentially of an intimate physical admixture of a non-aqueous excipient and at least about 1,500 ABC units of collagenase per gram of excipient.
A method of treating a wound or other condition of the body subject to topical treatment which comprises applying thereto a composition consisting essentially of a dry powdered intimate physical admixture of dextran as excipient and in excess of 5,000 ABC units of collagenase per gram of dextran.
A method of treating a wound or other condition of the body subject to topical treatment which comprises applying thereto a composition comprising an intimate physical admixture of a non-aqueous excipient and at least about 1,500 ABC units of collagenase per gram of excipient, said collagenase not being bound to the excipient by an added chemical binding agent.
A method for treating a wound or other condition of the body subject to topical treatment which comprises applying thereto a composition comprising a dry powdered intimate physical admixture of water-soluble dextran and from about 0.01 to about 30 weight per cent of a pharmaceutical suited for topical application, said pharmaceutical not being bound to the dextran by an added chemical binding agent.
A method for treating a wound or other condition of the body subject to topical treatment which comprises applying thereto a composition consisting essentially of a dry powdered intimate physical admixture of water-soluble dextran and from about 0.01 to about 30 weight per cent of a pharmaceutical suited for topical application.
Dependencies are inferred from the claim text.