Preparation of bone for transplantation
AssigneeOsteotech, Inc.
InventorsBrenda S. Morse, Clement D. Dioh
Life of this patent
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Abstract
A method of preparing bone for transplantation in which the internal matrix of the bone is contacted with an atmosphere at less than ambient pressure. The method may additionally, include a further step in which the bone is maintained in contact with a decontaminating agent or a detergent during the period of contact with the atmosphere.
Claims24
A method of preparing bone for transplantation, said bone containing an internal matrix comprising removable material, said method comprising:
- (a) contacting said bone or said matrix with a solution comprising a detergent or a decontaminating agent;
- (b) contacting said bone with an atmosphere having a pressure which is less than ambient pressure;
- and
- (c) contacting said bone or said matrix with a solution comprising a detergent or a decontaminating agent.
A method of treating bone that contains internal matrix itself comprising a predetermined amount of removable material having substantial affinity for said bone, said method comprising the step of contacting said matrix with an atmosphere at less than ambient pressure, and then maintaining said atmosphere in contact therewith for a time effective to reduce said amount of removable material below said predetermined value thereof.
A method of treating internal matrix of bone that contains a predetermined amount of removable material, said matrix containing also a predetermined amount of lipid that immobilizes substantially said removable material, said method comprising the step of contacting said matrix with an atmosphere at less than ambient pressure for a time effective to reduce said lipid content below said predetermined amount thereof.
A method of treating bone, said bone containing a section of internal matrix having at ambient pressure and in a defined space thereof, a predetermined amount of removable material, said method comprising subjecting space external to and in contact with said matrix to an atmosphere at less than ambient pressure for a time sufficient to reduce the amount of removable material remaining in said defined space below said predetermined amount thereof.
Dependencies are inferred from the claim text.