Back to results
US 5,512,687 AGranted
Compounds for inhibiting immune response
AssigneeProcept, Inc.
InventorCecilia M. Bastos
Life of this patent
Estimating the term…
Abstract
Novel ruthenium complexes for use as immunosuppressive agents to prevent or significantly reduce graft rejection in organ and bone marrow transplantation are described. The ruthenium complexes can also be used as an immunosuppressant drug for T-lymphocyte mediated autoimmune diseases, such as diabetes, and may be useful in alleviating psoriasis and contact dermatitis.
Claims5
A ruthenium complex of the general formula:
- RuM.sub.m !Z.sub.n
- wherein Ru is ruthenium having an oxidation state of 2 or 3;
- wherein M is the same or different and is independently a 5-membered ring that is a heterocyclic amine,
- wherein m is 6;
- wherein Z is a counterion of appropriate charge to render the overall charge of the complex neutral;
- wherein n is 0, 1, 2, 3 or 4.
3 more elements
Dependencies are inferred from the claim text.