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US 5,512,591 AGranted
Treatments for diseases characterized by neovascularization
AssigneePresident and Fellows of Harvard College
InventorsJose Halperin, Carlo Brugnara
Life of this patent
Estimating the term…
Abstract
Identified are particular class of imidazoles that inhibit anglogenesis. These imidazoles can be used to beneficially treat a variety of angiogenic conditions.
Claims24
A method for treating an angiogenic condition comprising:
- administering to a subject having a nonprostate nonhormone dependent solid tumor and in need of such treatment an imidazole that inhibits the Ca.sup.++ activated potassium channel of erythrocytes of the subject and that inhibits the vascular smooth muscle cell proliferation, wherein the imidazole is administered in amount effective to inhibit angiogenesis associated with said tumor and is selected from the group consisting of clotrimazole, miconazole and econazole of clotrimazole, miconazole and econazole.
A method for treating an angiogenic condition, comprising:
- administering to a subject having a nonprostate nonhormone dependent solid tumor, and in need of such treatment an imidazole that inhibits the Ca.sup.++ activated potassium channel of erythrocytes of the subject and that inhibits endothelial cell proliferation, wherein the imidazole is administered in an amount effective to inhibit angiogenesis associated with said tumor and is selected from the group consisting of clotrimazole, miconazole and econazole.
Dependencies are inferred from the claim text.