Furylthiazoles and their use as H.sub.2 - receptor antagonists and antimicrobials

A compound of the formula:

• ##STR7## wherein R.sup.1 is ethyl, propyl, butyl, hexyl, lower alkoxy(lower)alkyl, lower alkenyl, lower alkynyl, cyclo(lower) alkyl, heterocyclic(lower)alkyl selected from the group consisting of pyrrolyl(lower)alkyl, imidazolyl(lower)alkyl, pyrazolyl(lower)alkyl, triazolyl(lower)alkyl, tetrazolyl(lower)alkyl, pyridyl(lower)alkyl, pyrazinyl(lower)alkyl, pyrimidinyl(lower)alkyl, pyridazinyl(lower)alkyl, thiazolyl(lower)alkyl, thiadiazolyl(lower)alkyl, morpholinyl(lower)alkyl, pyrrolidinyl(lower)alkyl, imidazolidinyl(lower)alkyl, pyrazolidinyl(lower)alkyl, piperidyl(lower)alkyl, piperazinyl(lower)alkyl, benzothiazolyl(lower)alkyl, benzoisothiazolyl(lower)alkyl and benzothiadiazolyl(lower)alkyl or hydroxy(lower)alkyl,
• R.sup.2 is hydrogen,
• R.sup.3 is hydrogen or lower alkyl,
• R.sup.4 is amino, acyl selected from the group consisting of carbamoyl, thiocarbamoyl, sulfamoyl, lower alkanoyl, lower alkanesulfonyl, lower alkoxycarbonyl, lower alkenoyl, (C.sub.3 -C.sub.7) cycloalkanecarbonyl, lower alkoxalyl, lower alkanoylcarbonyl, lower alkanoyloxy(lower)alkanoyl, aroyl, arenesulfonyl, furoyl, thenoyl, nicotinoyl, 1-oxonicotinoyl, isonicotinoyl, thiazolylcarbonyl, thiadiazolylcarbonyl, tetrazolylcarbonyl, morpholinocarbonyl, phenyl(lower)alkanoyl, phenyl(lower)alkoxycarbonyl, phenoxy(lower) alkanoyl, thienylacetyl, imidazolylacetyl, furylacetyl, tetrazolylacetyl, thiazolylacetyl, thiadiazolylacetyl, thienylpropionyl, and thiadiazolylpropionyl, acylamino selected from the group consisting of carbamoylamino, thiocarbamoylamino, sulfamoylamino, lower alkanoylamino, lower alkanesulfonylamino, lower alkoxycarbonylamino, lower alkenoylamino, (C.sub.3 -C.sub.7) cycloalkanecarbonylamino, lower alkoxalylamino, lower alkanoylcarbonylamino, lower alkanoyloxy(lower)alkanoylamino, aroylamino, arenesulfonylamino, furoylamino, thenoylamino, nicotinoylamino, 1-oxonicotinoylamino, isonicotinoylamino, thiazolylcarbonylamino, thiadiazolylcarbonylamino, tetrazolylcarbonylamino, morpholinocarbonylamino, phenyl(lower)alkanoylamino, phenyl(lower)alkoxycarbonylamino, phenoxy(lower)alkanoylamino, thienylacetylamino, imidazolylacetylamino, furylacetylamino, tetrazolylacetylamino, thiazolylacetylamino, thiadiazolylacetylamino, thienylpropionylamino and thiadiazolylpropionylamino, lower alkylisothioureido, heterocyclic amino selected from the group consisting of pyrrolylamino, imidazolylamino, pyrazolylamino, triazolylamino, tetrazolylamino, pyridylamino, pyrazinylamino, pyrimidinylamino, pyridazinylamino, thiazolylamino, thiadiazolylamino, morpholinylamino, pyrrolidinylamino, imidazolidinylamino, pyrazolidinylamino, piperidylamino, piperazinylamino, benzothiazolylamino, benzoisothiazolylamino and benzothiadiazolylamino, a heterocyclic group selected from the group consisting of pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, thiazolyl, thiadiazolyl, morpholinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidyl, piperazinyl, benzothiazolyl, benzoisothiazolyl and benzothiadiazolyl, or a group of the formula:
• ##STR8## in which n is 0 or 1,
• X is .dbd.CH-- or .dbd.N--,
• R.sup.5 is hydrogen, cyano, nitro or acyl, and
• R.sup.6 is hydrogen, lower alkyl, lower alkylthio, lower alkoxy or amino which may have suitable substituent(s), and
• A is lower alkylene or --CONH--;
• or
• A--R.sup.4 is a heterocyclic group as defined above, and
• Q is hydrogen or lower alkyl,
• and pharmaceutically acceptable salt thereof.