Iminoxycarboxylates and derivatives as inhibitors of leukotriene biosynthesis

A compound of formula

• W--X--Q--Y--(CH(R.sup.1)).sub.n --O--N.dbd.C(R.sup.2)--A--COM
• or a pharmaceutically acceptable salt thereof wherein
• n is zero or 1 with the proviso that n is zero when Y is tetrahydronaphthyl;
• W is selected from the group consisting of
• (a) quinolyl, and
• (b) quinolyl substituted with
• halogen,
• alkyl of one to six carbon atoms, or
• alkoxy of one to six carbon atoms;
• X is selected from the group consisting of
• alkylene of one to six carbon atoms,
• alkenylene of two to six carbon atoms,
• alkynylene of two to six carbon atoms,
• alkoxy of one to six carbon atoms,
• thioalkyloxy of one to six carbon atoms, and
• alkylsulfonyl of one to six carbon atoms,
• Q is a valence bond or is selected from the group consisting of
• --O--,
• --S--,
• >NR.sup.4 where R.sup.4 is hydrogen, or alkyl of one to six carbon atoms, and
• >NCOR.sup.5 where R.sup.5 is alkyl of one to six carbon atoms, amino, or alkylamino of one to six carbon atoms;
• Y is selected from the group consisting of
• (a) phenyl,
• (b) phenyl substituted with
• halogen,
• alkyl of one to six carbon atoms, or
• alkoxy of one to six carbon atoms,
• (c) biphenyl,
• (d) biphenyl substituted with
• halogen,
• alkyl of one to six carbon atoms, or
• alkoxy of one to six carbon atoms,
• (e) naphthyl,
• (f) naphthyl substituted with
• halogen,
• alkyl of one to six carbon atoms, or
• alkoxy of one to six carbon atoms,
• (g) tetrahydronaphthyl,
• (h) tetrahydronaphthyl substituted with
• halogen,
• alkyl of one to six carbon atoms, or
• alkoxy of one to six carbon atoms;
• R.sup.1 is selected from the group consisting of
• (a) alkyl of one to twelve carbon atoms,
• (b) cycloalkyl of three to ten carbon atoms,
• (c) cycloalkyl of three to ten carbon atoms containing one atom selected from
• --O--,
• --S--,
• >NR.sup.4 where R.sup.4 is hydrogen, or alkyl of one to six carbon atoms, and
• >NCOR.sup.5 where R.sup.5 is alkyl of one to six carbon atoms, amino, or aminoalkyl of one to six carbon atoms,
• (d) alkoxyalkyl in which the alkoxy and alkyl portions independently are of one to twelve carbon atoms,
• (e) phenyl,
• (f) phenyl substituted with
• halogen,
• alkyl of one to six carbon atoms,
• haloalkyl of one to six carbon atoms, or
• alkoxy of one to six carbon atoms,
• (g) phenylalkyl in which the alkyl portion is of one to six carbon atoms,
• (h) phenylalkyl in which the alkyl portion is of one to six carbon atoms, and the phenyl ting is substituted with
• halogen,
• alkyl of one to six carbon atoms,
• haloalkyl of one to six carbon atoms, or
• alkoxy of one to six carbon atoms;
• R.sup.2 is selected from the group consisting of
• hydrogen,
• alkyl of one to six carbon atoms, and
• hydroxyalkyl of one to six carbon atoms;
• A is a valence bond or is selected from the group consisting of:
• (a) alkylene of one to six carbon atoms,
• (b) cycloalkylene of three to eight carbon atoms,
• (c) phenyl,
• (d) phenyl substituted with
• halogen,
• alkyl of one to six carbon atoms,
• haloalkyl of one to six carbon atoms, or
• alkoxy of one to six carbon atoms,
• (e) phenylalkyl in which the alkyl portion is of one to six carbon atoms,
• (f) phenylalkyl in which the alkyl portion is of one to six carbon atoms, and the phenyl ring is substituted with
• halogen,
• alkyl of one to six carbon atoms,
• haloalkyl of one to six carbon atoms, or
• alkoxy of one to six carbon atoms;
• M is selected from the group consisting of
• a pharmaceutically acceptable, metabolically cleavable group,
• --OR.sup.6 where R.sup.6 is selected from hydrogen or alkyl of one to six carbon atoms,
• --NR.sup.6 R.sup.7 wherein R.sup.7 is selected from
• hydrogen,
• alkyl of one to six carbon atoms,
• hydroxy,
• alkoxy or one to six carbon atoms.