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US 5,512,577 AGranted
Bicyclic hexahydroaporphine and 1-benzyloctahydroisoquinoline therapeutic compositions and processes for utilizing said compositions
AssigneeCreighton University
InventorsVictoria F. Roche, S. Edet Ohia, Edward B. Roche
Life of this patent
Estimating the term…
Abstract
The invention relates to the method of synthesis of bicyclic hexahydroaporphine compounds which may provide improved therapy for diseases characterized by an increase in intraocular pressure. More specifically, the present invention relates to the preparation of agents which may provide for improved treatment of patients with glaucoma or ocular hypertension. The present invention describes the intraocular pressure lowering capabilities of several of the bicyclic hexahydroaporphine structures.
Claims8
A pharmaceutical composition for controlling intraocular pressure, comprising:
- (a) an intraocular pressure lowering amount of a bicyclic hexahydroaporphine, or an opthalmalogically acceptable derivative form thereof;
- and
- (b) an opthalmalogically acceptable vehicle thereof, wherein said vehicle is selected from the group consisting of a preservative, an antioxidant and a buffer.
Dependencies are inferred from the claim text.