2-substituted 1,2,5,-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof

A compound of the formula:

• ##STR55## wherein R.sup.1 is hydrogen, lower-alkyl, or phenyl-lower-alkyl;
• R.sup.2 is hydrogen, lower-alkyl, or phenyl-lower-alkyl;
• R.sup.3 is hydrogen, or lower-alkyl;
• and --Z is a group of the formula:
• ##STR56## wherein X is hydrogen, halogen, lower-alkoxycarbonyl, lower-alkyl, phenyl, phenyl-lower-alkyl, phenylcarbonyl, lower-alkanoyl, 1-piperidinyl, 4-morpholinyl-lower-alkyl, or phenoxy;
• and --Y-- is --(CH.sub.2).sub.m --O--, --CHR--O--, --C(R).sub.2 --O--, --(CH.sub.2).sub.m --N(R')--, --CHR--N(R')--, --C(R.sub.2)--N(R')--, --C(R').dbd.C(R')--O--, --C(R').dbd.C(R')--N(R')--, --C(.dbd.O)--C(R").dbd.C(R")--, --C(Z').dbd.C(Z')--O--, --C(Z').dbd.C(Z')--N(R')--, --N(Z")--C(Z").dbd.N-- or --N.dbd.C(Z")--N(Z")-- wherein m is 1, 2, 3, or 4, R is the same or different lower-alkyl, phenyl or phenyl-lower-alkyl, R' is H or R, R" is H or R or the R" groups taken together with the carbon atoms to which they are bonded are furano, the Z' groups taken together with the carbon atoms to which they are bonded are benzo, furano, pyrido, pyrimidino or pyridazino, and the Z" groups taken together with the carbon or nitrogen atoms to which they are bonded are pyrido, pyrimidino or pyridazino.