Quinuclidine and azabicyclo 2.2.1! heptane pyrazinyl ethers as muscarinic agonists
AssigneeAmerican Home Products Corporation
InventorsGeorge E. M. Husbands, Joseph Tokolics
Life of this patent
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AssigneeAmerican Home Products Corporation
InventorsGeorge E. M. Husbands, Joseph Tokolics
Estimating the term…
The compound of the formula: ##STR1## in which Y is oxygen or sulfur; A is oxygen, sulfur or --NR.sub.2, where R.sub.2 is hydrogen or alkyl; R is --CH.sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2 CH(CH.sub.3).sub.2, --CH.sub.2 CF.sub.3, --CH.sub.2 CH.sub.2 CF.sub.3, --CH(CF.sub.3).sub.2, --CH.sub.2 CH(CF.sub.3).sub.2, --C.sub.3 H.sub.5, --CH.sub.2 C.sub.3 H.sub.5, --CH.sub.2 CH.sub.2 C.sub.3 H.sub.5, --C.sub.4 H.sub.7, --CH.sub.2 C.sub.4 H.sub.7, --C.sub.5 H.sub.9, --CH.sub.2 C.sub.9, --C.sub.6 H.sub.10, --CH.sub.2 C.sub.6 H.sub.10, --C.sub.4 H.sub.3 S, --CH.sub.2 C.sub.4 H.sub.3 S, --C.sub.6 H.sub.5 or --CH.sub.2 C.sub.6 H.sub.5 ; and n is one of the integers 1 or 2; or a pharmaceutically acceptable salt thereof are centrally active muscarinic agents.
A compound of the formula:
The compound of claim I which is (-)-(endo)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo 2.2.1!heptane or a pharmaceutically acceptable salt thereof.
A method of alleviating the symptoms of memory loss attending senility which comprises administering to a patient in need thereof, parenterally or orally, a muscarinic receptor active compound of the formula:
Dependencies are inferred from the claim text.