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US 5,512,569 AGranted
Aminoalkyl benzothiazolinones
AssigneeAdir et Compagnie
InventorsHamid A. Mansour, Thierry Taverne, Raymond Houssin, Isabelle Lesieur, Patrick Depreux, Geard Adam, Daniel-Henri Caignard, Pierre Renard, Marie-Claire Rettori
Life of this patent
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Abstract
The invention relates to the compounds of formula (I): ##STR1## in which R.sub.1 and R.sup.2 are as defined in the description, the optical isomers thereof, and an addition salt thereof with a pharmaceutically-acceptable acid or base, and medicinal product useful for treating a mammal afflicted with a disease associated with sigma receptors.
Claims10
A compound selected from those of formula (I):
- ##STR12## in which:
- R.sub.1 represents hydrogen or alkyl or substituted alkyl,
- and R.sub.2 represents a group of formula R.sub.21 :
- ##STR13## in which:
- R.sub.3 and R.sub.4 together form a saturated 5- to 9-membered heterocycle which may contain other hetero atoms chosen from oxygen and sulfur and which may be unsubstituted or substituted or 4-(methoxyphenyl)-piperazin-1-yl,
- or a group of formula R.sub.22 :
- ##STR14## in which n represents 2, 3 or 4,
- and R.sub.5 and R.sub.6, which are identical, represent hydrogen or halogen,
- it being understood that in the formula (I),
- the term "substituted" associated with the heterocycle formed by --NR.sub.3 R.sub.4 means that the substitution may be made by one or more alkyl,
- the terms "alkyl" and "alkoxy" denote linear or branched groups containing 1 to 6 carbon atoms inclusive,
- an optical isomer thereof, and an addition salt thereof with a pharmaceutically-acceptable acid or, when R.sub.1 represents hydrogen, an addition salt thereof with a pharmaceutically-acceptable base.
9 more elements
Dependencies are inferred from the claim text.