Tricyclic thiazole and oxazole derivatives and pharmaceutical agents containing them

Pyrrole compounds of the formula ##STR59## wherein HET is a heterocyclic ring which is a member selected from the group consisting of aziridine, furan, tetrahydrofuran, thiophene, thiolan, sulfonal, pyrrole, pyrrolidine, oxazole, oxazoline, isoxazole, thiazole, thiozolidine, pyrazole, pyrazoline, imidazole, imidazoline, oxadiazole, furan, thiazole, pyridine, piperidine, morpholine, thiazine, pyridazine, pyrimidine, pyrazine, piperazine and azepine, and N-oxide, dihydro and tetrahydro hydrogenated rings of said member, wherein said member are substituted by at least one R.sup.1 moiety;

• R.sup.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.7 alkenyl, C.sub.2 -C.sub.7 alkinyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylmercapto, C.sub.1 -C.sub.6 alkylsulfinyl, C.sub.1 -C.sub.6 alkylsulfonyl, amino, C.sub.1 -C.sub.6 alkylamino di-C.sub.1 -C.sub.6 alkylamino, sulfomamido, C.sub.1 -C.sub.6 alkoxycarbonyl, carboxy, halogen, hydroxy, nitro, cyano, azido, phenyl or benzyloxy;
• Y is oxygen, sulphur, SO or SO.sub.2 ;
• X is an oxygen or sulphur atom;
• R is (a) C.sub.1 -C.sub.9 alkyl, C.sub.2 -C.sub.7 alkenyl or C.sub.2 -C.sub.7 alkinyl, wherein said alkyl, alkenyl and alkinyl radicals, which can be straight-chained or branched, are unsubstituted or substituted by phenyl,
• b) phenyl or a mono, bi or tricyclic carbocyclic ring containing 7-15 ring carbon atoms, or
• c) a heterocyclic ring selected from the group consisting of the pyridine, pyrimidine, pyridazine, pyrazine, triazine, pyrrole, pyrazole, imidazole, triazole, thiazole, oxazole, isoxazole, oxadiazole, furazan, furan, thiophene, indole, quinoline, isoquinoline, coumarone, thionaphthene, benzoxazole, benzthiazole, indazole, benzimidazole, benztriazole, chromene, phthalazine, quinazoline, quinoxaline, methylenedioxybenzol, carbazole, acridine, phenoxazine, phenothiazine, phenazine and purine, and N-oxide, partially hydrogenated and completely hydrogenated Ring systems thereof, wherein the carbocyclic rings and the heterocyclic rings are unsubstituted or substituted by at least one substituent selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylmercapto, C.sub.1 -C.sub.6 alkylsulfinyl, C.sub.1 -C.sub.6 alkylsulfonyl, C.sub.2 -C.sub.7 alkenyl, C.sub.2 -C.sub.7 alkinyl, C.sub.2 -C.sub.7 alkenyloxy, C.sub.2 -C.sub.7 alkenylmercapto, C.sub.2 -C.sub.7 alkinyloxy, C.sub.2 -C.sub.7 alkinylmercapto, amino, C.sub.1 -C.sub.6 alkylamino, di-C.sub.1 -C.sub.6 alkylamino, C.sub.1 -C.sub.6, alkyl-carbonylamino, C.sub.1 -C.sub.6 alkylaminocarbonyl, C.sub.1 -C.sub.6 alkoxycarbonyl, hydroxy, benzyloxy, phenylmercapto, phenyloxy, nitro, cyano, halogen, trifluoromethyl, azido, formylamino, carboxy and phenyl,
• R.sup.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylmercapto, amino, C.sub.1 -C.sub.6 alkylamino, di-C.sub.1 -C.sub.6 alkylamino, halogen, cyano, hydroxy, carboxy, C.sub.1 -C.sub.6 alkoxycarbonyl, aminocarbonyl or C.sub.1 -C.sub.6 alkylaminocarbonyl,
• R.sup.3, R.sup.4 and R.sup.5, which are the same or different, have the same meanings as R.sup.2, or R.sup.3 and R.sup.4 together represent a double bond;
• or tautomers, enantiomers, diastereomers or a physiologically acceptable salt thereof.