Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
AssigneeG. D. Searle & Co.
InventorsNizal S. Chandrakumar, Horng-Chih Huang, Richard A. Mueller
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Abstract
The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, and for the treatment of prostaglandin E.sub.2 -mediated diseases, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, a method for eliminating or ameliorating pain in an animal, and a method for treating prostaglandin E.sub.2 -mediated diseases in an animal, comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
Claims6
A pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a therapeutically-effective amount of a compound having a structure:
- ##STR64## or a pharmaceutically-acceptable salt thereof, wherein:
- X is hydrogen, halogen or --CF.sub.3 ;
- Y is hydrogen or halogen;
- Z is oxygen, sulfur, ##STR65## R is ##STR66## Ar is aryl;
- and R.sup.1 is hydrogen, halogen, aryl, alkylaryl, alkenylaryl, alkynylaryl, carboxy, carbonylalkoxy or carbonylaminoalkylaryl,
- with the proviso that R is not --CH.sub.2 -- when R.sup.1 is carboxy, phenyl or alkylphenyl.
A method for treating pain in a mammal comprising administering to said mammal a therapeutically-effective amount of a compound having a structure:
- ##STR67## or a pharmaceutically-acceptable salt thereof, wherein:
- X is hydrogen, halogen or --CF.sub.3 ;
- Y is hydrogen or halogen;
- Z is oxygen, sulfur, ##STR68## R is ##STR69## Ar is aryl;
- and R.sup.1 is hydrogen, halogen, aryl, alkylaryl, alkenylaryl, alkynylaryl, carboxy, carbonylalkoxy or carbonylaminoalkylaryl,
- with the proviso that R is not --CH.sub.2 --when R.sup.1 is carboxy, phenyl or alkylphenyl.
A method for treating prostaglandin E.sub.2 -mediated diseases in a mammal comprising administering to said mammal a therapeutically-effective amount of a compound having a structure:
- ##STR70## or a pharmaceutically-acceptable salt thereof, wherein:
- X is hydrogen, halogen or --CF.sub.3 ;
- Y is hydrogen or halogen;
- Z is oxygen, sulfur, ##STR71## R is ##STR72## Ar is aryl;
- and R.sup.1 is hydrogen, halogen, aryl, alkylaryl, alkenylaryl, alkynylaryl, carboxy, carbonylalkoxy or carbonylaminoalkylaryl,
- with the proviso that R is not --CH.sub.2 -- when R.sup.1 is carboxy, phenyl or alkylphenyl.
Dependencies are inferred from the claim text.