Nor-bile acid derivatives, processes for their preparation and the use of these compounds as medicaments

A bile acid derivative of the formula I

• G.sub.1 --X--G.sub.2
• wherein G.sub.1 is linked via the side chain on atom No. 17 with the bonding member X to atom No. 3 of G.sub.2, and G.sub.1 is a radical of the formula II ##STR144## in which Z is one of the following radicals ##STR145## or a single bond, R(1) is H, an alkyl radical having 1 to 10 carbon atoms or an alkenyl radical having 2 to 10 carbon atoms,
• R(2), R(3), R(4), R(5) are independently H, OH or
• R(2) and R(3), or R(4) and R(5) together form the oxygen of a carbonyl group,
• X is a single bond or a bridge member of the formula III ##STR146## in which A is an alkylene chain, which is branched or unbranched, and which is optionally interrupted by --O--, --S--, or phenylene, the linkage of the phenyl ring being in the ortho-, meta- or para-position and the chain comprising 2 to 12 chain members,
• B is an alkylene chain which is branched or unbranched, and which is optionally interrupted by --O--, --S--, or phenylene, the linkage of the phenyl ring being in the ortho-, meta- or para-position and the chain comprising 2 to 12 chain members,
• L(1), L(2) and L(3) are identical or different and are selected from H, an alkyl radical or alkenyl radical having up to 10 carbon atoms, a cycloalkyl radical having 3 to 8 carbon atoms, a phenyl radical, which is unsubstituted or mono- to trisubstituted by F, Cl, Br, (C.sub.1 -C.sub.4 -alkyl or (C.sub.1 -C.sub.4 -alkoxy, or a benzyl radical, which is unsubstituted or mono- to trisubstituted by F, Cl, Br, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-alkoxy,
• q is 0 to 5;
• r is 0 or 1;
• s is 0 or 1;
• and
• t is 0 or 1,
• G.sub.2 is a radical of the formula IV ##STR147## in which Z is one of the following radicals ##STR148## or a single bond, with the proviso that Z may be ##STR149## in only one of formulas II and IV;
• V is --O-- or ##STR150## when W is H or,
• V is --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 -- when W is H or OH,
• Y is --OL, NHL, ##STR151## or an amino acid or amino-sulfonic acid bonded via the amino group, selected from the group consisting of --NH--CH.sub.2 --COOH, --NH--CH.sub.2 --CH.sub.2 --, SO.sub.3 H, ##STR152## in which L is H, an alkyl radical or alkenyl radical having up to 10 carbon atoms, a cycloalkyl radical having 3 to 8 carbon atoms, a phenyl radical, which is unsubstituted or mono- to trisubstituted by F, Cl, Br, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-alkoxy, or a benzyl radical, which is unsubstituted or mono- to trisubstituted by F, Cl, Br, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-alkoxy, and
• R(6), R(7), R(8), R(9) are independently H, OH or
• R(6) and R(7) or R(8) and R(9) together form the oxygen of a carbonyl group.