Method of treating hyperproliferative skin diseases with fluorinated vitamin D.sub.3 analogs
AssigneeHoffmann-La Roche Inc.
InventorsEnrico G. Baggiolini, deceased, Shian-Jan Shiuey, Milan R. Uskokovic
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Abstract
Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine, and X is H.sub.2 or .dbd.CH.sub.2 are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of cancer, such as, leukemia, and as agents for the treatment of sebaceous gland diseases, such as, acne and seborrheic dermatitis.
Claims10
A method for the treatment of hyperproliferative diseases of the skin which comprises administering to a warm blooded animal in need of such treatment an effective amount of a compound of the formula ##STR12## wherein R is hydrogen, hydroxy, or fluorine and X is H.sub.2.
A method for the treatment of leukemia which comprises administering to a warm blooded animal in need of such treatment an effective amount of a compound of the formula ##STR13## wherein R is hydrogen, hydroxy or fluorine, X is H.sub.2.
Dependencies are inferred from the claim text.