Bisphosphonic acid derivatives, and pharmaceutical use
AssigneeTakeda Chemical Industries, Ltd.
InventorsTakashi Sohda, Iwao Yamazaki, Noriaki Kawamura, Shigehisa Taketomi
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Abstract
A bisphosphonic acid derivative of the general formula (I): ##STR1## wherein A is an optionally substituted cyclic group; R.sup.1 is hydrogen atom or a lower alkanoyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and are hydrogen atom or a lower alkyl group; m is 0, 1 or 2; and n is an integer from 2 to 10, or a salt thereof is disclosed. A process for its production and a bone resorption inhibitor containing the compound of the general formula (I) or a salt thereof are also disclosed.
Claims9
A bisphosphonic acid derivative of formula (I):
- ##STR126## wherein A is an optionally substituted C.sub.6-14 aromatic hydrocarbon group;
- R.sup.1 is a hydrogen atom or a lower alkanoyl group;
- R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and are a hydrogen atom or a lower alkyl group;
- m is 0, 1 or 2;
- and n is an integer from 2 to 10, or a pharmaceutically acceptable salt thereof.
A method for inhibiting bone resorption comprising administering an effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt thereof optionally together with a pharmaceutically acceptable carrier, diluent or excipient to a patient suffering from osteoporosis.
Dependencies are inferred from the claim text.