Back to results
US 5,512,549 AGranted
Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
AssigneeEli Lilly and Company
InventorsVictor J. Chen, Richard D. DiMarchi, David L. Smiley, Russell D. Stucky, Aidas V. Kriauciunas
Life of this patent
Estimating the term…
Abstract
Glucagon-like insulinotropic peptide (GLP-1(7-37)) analogs and derivatives are disclosed. The analogs include amino acid substitutions, amino and carboxyl terminal modifications, and C.sub.6 -C.sub.10 acylations. The claimed compounds stimulate the secretion or biosynthesis of insulin in poorly functioning beta cells and are therefore useful in treating Type II diabetics
Claims28
A compound of the formula:
- ##STR5## wherein R.sup.1 is selected from the group consisting of 4-imidazopropionyl, 4-imidazoacetyl, or 4-imidazo-.alpha.,.alpha.dimethylacetyl;
- R.sup.2 is selected from the group consisting of C.sub.6 -C.sub.10 unbranched acyl, or is absent;
- R.sup.3 is selected from the group consisting of Gly-OH or NH.sub.2 ;
- and,
- Xaa is Lys or Arg.
2 more elements
Dependencies are inferred from the claim text.