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US 5,512,545 AGranted
PDGF-B analogues
AssigneesBritish Biotech Pharmaceuticals Limited, Pfizer Inc.
InventorsDavid Brown, Richard M. Edwards, Stewart Craig, Anne L. Cook, John M. Clements
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Abstract
PDGF-B analogues are prepared in which an amino acid residue at a protease site is replaced with the corresponding amino acid residue from PDGF-A. The polypeptide is obtained at yields which are five to ten times greater than that for naturally occurring PDGF-B and retains the biological activity of the natural polypeptide.
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