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AssigneeCoulter Corporation
InventorsCarole Young, Michael N. Elliott, Timothy J. Fischer, Nancy R. Naylor
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A hematology control product comprising leukocyte analogs is described. The analogs comprise red blood cells which simulate at least two physical properties of human leukocytes. A method for making leukocyte analogs from blood cells having desired physical properties is also described. The process comprises expanding the cell volume, changing the hemoglobin content of the cell and fixing the cell. Generally, the monocyte and lymphocyte analogs leak hemoglobin from the cell while the eosinophil analog has the hemoglobin precipitated in the cell. A further method is described to use the control product to determine whether an automatic instrument is operating within manufacturer's specification.
A hematology control product which contains a leukocyte subpopulation analog comprising a red blood cell that has been treated so that said red blood cell has an increase in volume greater than 50% of its original volume and is resistant to degradation by lytic reagents used in hematological test procedures, and wherein said control product has at least two physical properties of a subpopulation of a human leukocyte, said properties comprising:
A method for using a hematology control product which contains a leukocyte subpopulations analog comprising:
Dependencies are inferred from the claim text.