Process for producing optically active 1,3-butanediol
AssigneeDaicel Chemical Industries, Ltd.
InventorsAkinobu Matsuyama, Yoshinori Kobayashi
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Abstract
Optically active 1,3-butanediol can be obtained by treating an enantiomorphic mixture of 1,3-butanediol with a microorganism or cells thereof which have been ground, acetone-treated, or lyophilized capable of acting on an enantiomorphic mixture of 1,3-butanediol so as to leave (R)- or (S)-1,3-butanediol as such. Further, optically active 1,3-butanediol can be obtained by treating 4-hydroxy-2-butanone with a microorganism or cells thereof which have been ground, acetone-treated, or lyophilized capable of asymmetrically reducing the 4-hydroxy-2-butanone into (R)- or (S)-1,3-butanediol.
Claims13
A process for producing optically active 1,3-butanediol comprising contacting 4-hydroxy-2-butanone with viable cells of a microorganism or cells thereof which have been ground, acetone-treated, or lyophilized, selected from the group consisting of Agrobacterium radiobacter, Azotobacter chroococcum, Bordetella bronchiseptica, Brettanomyces abstines, Dekkera bruxellensis, Endomyces decipiens, Eremascus fertilis, Erwinia carotovora subsp carotovora, Fusarium oxysporum, Fusarium solani, Geotrichum fragrans, Gibberella fujikuroi, Gonatobotryum apiculatum, Klebsiella pneumoniae, Micrococcus luteus, Micrococcus roseus, Mycobacterium smegmatis, Neosartorya fischeri var spinosa, Oospora astringenes, Pachysolen tannophilus, Paecilomyces variotii, Paracoccus denitrificans, Preussia terricola, Saccharomycopsis fibuligera, Serratia marcescens, Syringospora claussenii, Septoria glycines, Sporopachydermia lactativora, Talaromyces flavus var flavus, Westerdykella multispora, Zygoascus hellenicus, and Zygozyma oligophaga capable of asymmetrically reducing 4-hydroxy-2-butanone into (R) -1,3-butanediol, and then recovering the (R)-1,3-butanediol thus formed.
A process for producing optically active 1,3-butanediol, comprising contacting 4-hydroxy-2-butanone with viable a microorganism or cells thereof which have been ground, acetone-treated, or lyophilized, selected from the group consisting of Aciculoconidium aculeatum, Brettanomyces anomala, Clavispora lusitaniae, Cochliobolus miyabeanus, Corynespora cassiicola, Dactylium dentroides, Echinopodospora jamaicensis, Enterobacter cloacae, Hamigera avellanea, Helminthosporium sigmoideum vat irregulare, Kloeckera africana, Nectria cinnabarina, Pseudomonas diminuta, Phialocephala bacterospora, Rhodotorula glutinis, Saccharomyces cerevisiae, Sterigmatomyces elviae, and Schizoblastosporion kobayasii capable of asymmetrically reducing 4-hydroxy-2-butanone into (S) -1,3-butanediol, and then recovering the (S)-1,3-butanediol thus formed.
Dependencies are inferred from the claim text.