Cytokine designated elk ligand
AssigneeImmunex Corporation
InventorsStewart Lyman, M. Patricia Beckmann, Peter R. Baum, Melissa K. Carpenter
Life of this patent
Estimating the term…
Abstract
elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface receptor that is a member of the tyrosine kinase receptor family.
Claims13
An isolated DNA sequence encoding a human elk-L protein wherein said elk-L comprises an amino acid sequence selected from the group consisting of amino acids -24 to 322 of SEQ ID NO:2 and 1-322 of SEQ ID NO:2.
An isolated nucleic acid molecule comprising a sequence of at least about 14 nucleotides of the DNA sequence presented in SEQ ID NO:1 or its DNA or RNA complement.
An isolated DNA sequence encoding a soluble human elk-L protein, wherein said elk-L comprises an amino acid sequence selected from the group consisting of amino acids -24 to 213 of SEQ ID NO:2 and 1-213 of SEQ ID NO:2.
An isolated DNA sequence encoding an elk-L protein which binds elk, wherein the mature form of said elk-L is characterized by:
- a) a calculated molecular weight of about 35,180 daltons;
- b) a calculated pI of about 9.006;
- and
- c) the N-terminal amino acid sequence:
- Ala-Thr-Pro-Leu-Ala-Lys-Asn-Leu-Glu-Pro-Val-Ser-(amino acids 1-12 of SEQ ID NO:2).
Dependencies are inferred from the claim text.