Method for determining head and neck squamous cell carcinomas, prostate carcinomas, and bladder tumors by assaying for mage-3
AssigneeLudwig Institute for Cancer Research
InventorsBeatrice Gaugler, Thierry Boon-Falleur, Benoit van den Eynde, Etienne DePlaen, Francis Basseur, Bernard Lethe, Pierre van der Bruggen
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Abstract
A method for determining head and neck squamous cell carcinomas, bladder tumors and prostate carcinomas is described. The method involves assaying for expression of the gene coding for tumor rejection antigen precursor MAGE-3, or its expression product. Various assays, and kits useful for these assays, are described.
Claims11
Method for screening for possible presence of cancer, wherein said cancer is selected from the group consisting of head squamous cell carcinoma, neck squamous cell carcinoma, and prostate carcinoma, comprising assaying a tissue sample taken from the head, neck or prostate gland of a subject believed to have a head squamous cell carcinoma, a neck squamous cell carcinoma or a prostate carcinoma, and determining expression of mRNA for a MAGE-3 gene, as a determination of possible presence of said cancer in said subject.
Method for screening for possible presence of cancer, wherein said cancer is selected from the group consisting of head squamous cell carcinoma, neck squamous cell carcinoma, and prostate cancer, comprising assaying a tissue sample taken from the head, neck or prostate gland of a subject believed to have a head squamous cell carcinoma, a neck squamous cell carcinoma or a prostate carcinoma and determining expression of MAGE-3 protein, as a determination of possible presence of said cancer in said subject.
The method of 7, comprising determining expression of MAGE-3 protein by immunoassay.
Isolated nucleic acid molecule selected from the group consisting of SEQ ID NO:1, and SEQ ID NO:2.
Kit useful in determining expression of mRNA for MAGE-3 gene in a cell sample, comprising separated portions of each of SEQ ID NO:1 and SEQ ID NO:2, and a means for containing both of said separate nucleic acid molecules.
Dependencies are inferred from the claim text.