Invitroinhibition of the HIV virus with ionic tungstoniobate compounds
OwnerMichael J. Abrams, Gerald E. Bossard +3inventors
InventorsMichael J. Abrams, Gerald E. Bossard, Craig L. Hill, Raymond F. Schinazi, Brian R. C. Theobald
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Abstract
Tungstoniobate compounds containing an ion of general formula A.sub.x W.sub.y Nb.sub.a O.sub.b !.sup.p- I where A=P, Si, Ge, x=0 or an integer from 1 to 10, y is an integer from 1 to 10, y is an integer from 1 to 40, a is an integer from 1 to 8, b is an integer from 15 to 150, and p is an integer dependent upon the nature and oxidation state of element A, have been found to be active against viruses including especially HIV and Herpes Simplex. Pharmaceutical compositions and methods of treatment are disclosed.
Claims6
A method for the in vitro inhibition of the HIV virus, comprising contacting said virus with an ionic tungstoniobate compound selected from those containing ions of formula (I)
- A.sub.x W.sub.y Nb.sub.a O.sub.b !.sup.p- I
- wherein
- A is one or more element selected from the group consisting of H, P, Si and Ge;
- x is zero or an integer from 1 to 10;
- y is an integer from 1 to 40;
- a is an integer from 1 to 8;
- b is an integer from 15 to 150;
- and
- p is an integer dependent upon the nature and oxidation state of element A,
- and their aqua complexes and active fragments.
The method of one of the preceding claims, wherein said tungstoniobate compound has as counter-ions, hydrogen, alkali metal, alkaline earth metal, ammonium substituted ammonium or another basic nitrogen-containing organic compound.
Dependencies are inferred from the claim text.