Injectable pharmaceutical composition
AssigneeAplicaciones Farmaceuticas S.A. de C.V.
InventorsJosue Garza Flores, Laura P. Laiseca Soto, Jose Guillen Pichardo, Juan Angeles Uribe
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Abstract
Formulations of programmed-release medicinal products intended for parenteral administration by injection, comprising calibrated solid microspheres (1 to 300 microns) of active substances. Provided in this form, steroids (for example progesterone and 17-.beta.-estradiol) may constitute injectable contraceptives, and the action of drugs having an approximatively 24 hours lasting effect may be regulated and extended.
Claims8
Solid, non-porous microspheres having a diameter in the range of from 1-300 .mu.m, wherein said microspheres consist essentially of an injectable analgesic having a melting temperature above 60.degree. C. and thermostable above its melting point and wherein said microspheres are obtained by spraying said analgosic in the melted state to form droplets and rapidly freezing said droplets.
A method of improving the consistency of the pharmacokinetic and pharmacological effect of an injectable analgesic having a melting temperature above 60.degree. C. and thermostable above it smelting point, comprising transforming said analgesic into microspheres having an average diameter in the range of from 1-300 .mu.m and wherein said microspheres are obtained by spraying said analgesic in the melted state to form droplets and rapidly freezing said droplets.
Dependencies are inferred from the claim text.