Prevention of ibuprofen from forming low melting eutectics with other therapeutic agents in solid dosage forms
AssigneeWarner-Lambert Company
InventorsTimothy H. Weng, Michael G. Williams
Life of this patent
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Abstract
A method for preparing ibuprofen granulations which exhibit improved stability and resistance to the formation of low melting point eutectics is disclosed. The method includes forging an amalgamation of ibuprofen and an alkali metal in a physical matrix which is suitable for inclusion in a composition without destroying the amalgamation. The stabilized ibuprofen granulation can be combined with other active ingredients and/or excipients to form compositions which have extended shelf life and are resistant to the formation of low melting point eutectics.
Claims22
A method of stabilizing ibuprofen for use in a composition comprising:
- a) directly heating ibuprofen to form a melt;
- b) combining said ibuprofen melt with an alkali metal to forge an amalgamation;
- and
- c) mixing the ibuprofen melt with the alkali metal to form a homogenous paste suitable for inclusion in a composition without disrupting said amalgamation.
Dependencies are inferred from the claim text.