Cytarabine ocfosfate hard capsule
AssigneeNippon Kayaku Kabushiki Kaisha
InventorsMinoru Aoki, Hiroshi Ohtaki, Nobuharu Fukui, Takashi Terada, Minoru Nakada, deceased
Life of this patent
Estimating the term…
Abstract
The present invention relates to hard capsules of cytarabine ocfosfate which is useful as an anti-leukemia drug applicable to oral administration. By providing the cytarabine ocfosfate hard capsule comprising (1) cytarabine ocfosfate, (2) a high molecular compound functioning as a disintegrator and (3) an alkali, there can be provided pharmaceutical preparations having excellent disintegration property and stability. The cytarabine ocfosfate hard capsules are applicable to clinical use.
Claims7
A cytarabine ocfosfate hard capsule comprising (1) cytarabine ocfosfate, (2) a high molecular compound functioning as a disintegrator Selected from the group consisting of a hydroxypropyl cellulose having a propylation rate of the hydroxy group in the range of 7% to 16%, sodium carboxymethyl starch, pregelatanized starch and crosslinked polyvinylpyrrolidone;
- and (3) an alkali.
A hard capsule comprising (1) 5 to 50 W/W % of cytarabine ocfosfate, (2) 10 to 80 W/W % of a hydroxypropyl cellulose having a propylation rate of the hydroxy groups in the range of 7% to 16%, and (3) 0.1 to 8.0 W/W % of sodium carbonate in terms of a proportion based on the weight of the composition.
Dependencies are inferred from the claim text.