Oral sustained release drug delivery device
AssigneeAlza Corporation
InventorsFelix A. Landrau, Patricia S. Campbell, Arthur W. Hall, Juan M. E. Harrison
Life of this patent
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Abstract
This invention pertains to a sustained release delivery device for delivering a beneficial agent into the oral cavity of a patient. More particularly, the invention relates to a device comprising about 0.1% to about 20% by weight beneficial agent, about 40% to about 95% by weight ethylene vinyl acetate copolymer having a vinyl acetate content of about 4% to about 80% and about 1% to about 60% by weight polyvinyl pyrrolidone.
Claims25
A sustained release delivery device for administering beneficial agent continuously to the oral cavity of an animal for 0.5 to 12 hours at a controlled rate, said device comprising:
- (a) a size and shape for comfortably retaining the device in the oral cavity for 0.5 to 12 hours;
- and
- (b) a matrix consisting essentially of about 0.1% to about 20% by weight beneficial agent, about 40% to about 95% by weight ethylene vinyl acetate copolymer having a vinyl acetate content of about 4% to about 80% and about 1% to about 60% by weight polyvinyl pyrrolidone.
A sustained release delivery device for administering beneficial agent continuously to the oral cavity of an animal for 0.5 to 12 hours at a controlled rate, said device comprising:
- (a) a size and shape for comfortably retaining the device in the oral cavity for 0.5 to 12 hours;
- (b) a matrix consisting essentially of about 0.1% to about 20% by weight beneficial agent, about 40% to about 95% by weight ethylene vinyl acetate copolymer having a vinyl acetate content of about 4% to about 80% and about 1% to about 60% by weight polyvinyl pyrrolidone;
- and
- (c) adhesive means for maintaining the matrix adhered to the mucosa of the oral cavity.
A sustained release delivery device for administering beneficial agent continuously to the oral cavity of an animal for 0.5 to 12 hours at a controlled rate, said device comprising:
- (a) a size and shape for comfortably retaining the device in the oral cavity for 0.5 to 12 hours;
- (b) a matrix consisting essentially of about 0.1% to about 20% by weight beneficial agent, about 40% to about 95% by weight ethylene vinyl acetate copolymer having a vinyl acetate content of about 4% to about 80% and about 1% to about 60% by weight polyvinyl pyrrolidone;
- (c) a barrier that is impermeable to beneficial agent on the mucosa-distal surface of the matrix;
- and
- (d) adhesive means for maintaining the matrix adhered to the mucosa of the oral cavity.
A sustained release delivery device for administering beneficial agent continuously to the oral cavity of an animal for 0.5 to 12 hours at a controlled rate, said device comprising:
- (a) a size and shape for comfortably retaining the device in the oral cavity for 0.5 to 12 hours;
- (b) a matrix consisting essentially of about 0.1% to about 20% by weight beneficial agent, about 40% to about 95% by weight ethylene vinyl acetate copolymer having a vinyl acetate content of about 4% to about 80% and about 1% to about 60% by weight polyvinyl pyrrolidone;
- (c) a barrier that is impermeable to beneficial agent on the mucosa-proximal surface of the matrix;
- and
- (c) means for maintaining the matrix adhered to the mucosa of the oral cavity.
Dependencies are inferred from the claim text.