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US 5,512,291 AGranted
Method of making resorbable vascular wound dressing
OwnerShu-Tung Liinventor
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Abstract
The present invention is related to prostheses, their methods of manufacture and methods for repairing vascular lesions using such prostheses. Natural polymers such as collagen are processed and fabricated to form tubular resorbable vascular wound dressings with unique physico-chemical and mechanical properties for repairing selected vascular segments, and for delivering therapeutic agents at selected sites within vessels and at the anastomoses.
Claims10
A method of making a self-expandable resorbable vascular wound dressing for repairing a blood vessel comprising:
- a) forming an aqueous dispersion containing type I collagen;
- b) coacervating the collagen with a coacervating agent to form coacervated collagen fibers;
- c) placing the coacervated collagen fibers into a coaxial cylindrical mold;
- d) freeze drying the fibers in the mold to form a dried collagen matrix conduit;
- e) spraying the freeze dried collagen matrix conduit with water mist;
- f) compressing the water mist treated collagen matrix conduit;
- g) compressing the ends of the collagen matrix conduit to form an inwardly converging tapered inner diameter;
- and then
- h) crosslinking the compressed collagen matrix conduit with a crosslinking agent.
6 more elements
Dependencies are inferred from the claim text.