Monospecific polyclonal antibodies to shiga-like toxins
AssigneeMicroCarb, Inc.
InventorsHoward C. Krivan, James E. Samuel
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Abstract
Disclosed herein are high titer, monospecific, polyclonal antibodies to Shiga-like toxins. Also disclosed are methods for producing such antibodies, compositions containing them, and methods for the diagnosis, prevention, and treatment of diseases caused by Shiga-like toxins. These include hemorrhagic colitis and hemolytic uremic syndrome in humans, edema disease in swine, and calf diarrhea in cattle.
Claims18
Purified IgG, comprising high titer, monospecific polyclonal antibodies to Shiga-like toxin (SLT) obtained by a process comprising the steps of:
- inoculating a bovine animal with a purified, active SLT, derived from E. coli and selected from the group consisting of SLT I, SLT II, SLT IIV and mixtures thereof;
- and
- recovering and purifying IgG from said animal after said animal has had an immune response to said purified active SLT.
A method for producing high titer, monospecific, polyclonal antibodies to Shiga-like toxin (SLT) comprising the steps of:
- inoculating a bovine animal with a purified, active SLT, derived from E. coli and selected from the group consisting of SLT I, SLT II, SLT IIV and mixtures thereof;
- and
- recovering and purifying IgG from said animal after said animal has had an immune response to said purified active SLT.
Dependencies are inferred from the claim text.