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AssigneeDuke University
InventorsAndrew J. Ghio, Claude A. Piantadosi, Thomas P. Kennedy
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The present invention relates to use of alkylaryl polyether alcohol polymers as antioxidants to suppress certain oxidant chemical reactions that cause tissue injury and disease in mammals. Disclosed is a method of inhibiting oxidants using alkylaryl polyether alcohol polymers. More particularly, disclosed is a method for the treatment of mammalian disease entities related to overproduction of partially reduced oxygen species comprising administering to a mammal a treatment effective amount of an alkylaryl polyether alcohol polymer. The mammalian disease entities include, but are not limited to, myocardial infarction, stroke, adult respiratory distress syndrome, oxygen toxicity of the lung, lung injury from asbestos, Parkinson's disease, thermal and solar burns of the skin, and injury to the gastrointestinal tract from nonsteroidal anti-inflammatory agents.
A method for the treatment of mammalian disease entities resultant from oxidant species consisting essentially of administering to a mammal an amount of alkylaryl polyether alcohol polymer of the formula ##STR2## where, R=ethylene, R.sup.1 =tertiary octyl, x is greater than 1, and y=8 to 18, effective to inhibit oxidant chemical reactions caused by the oxidant species in the mammal, thereby treating the mammalian disease entities.
Dependencies are inferred from the claim text.