Method for preparing aqueous emulsion for coating solid pharmaceutical preparations
AssigneeShin-Etsu Chemical Co., Ltd.
InventorsNaosuke Maruyama, Hiroyasu Kokubo, Shin-Ichiro Nakamura
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Abstract
A method for preparing an aqueous emulsion for coating solid pharmaceutical preparations comprises the steps of dissolving a cellulosic polymer in a mixed solvent of water and an organic solvent capable of being admixed with water in any rate to give a polymer solution, self-emulsifying the polymer solution by mixing with water and then concentrating the resulting emulsified stock solution. The concentration is carried out by removing a part of the liquid components while passing it through a membrane for ultrafiltration till the polymer concentration of the resulting emulsion reaches a level of not less than 7% by weight.
Claims10
A method for preparing an aqueous emulsion for coating solid pharmaceutical preparations comprising the following steps (a) to (c):
- (a) dissolving a water-insoluble cellulosic polymer in an organic solvent capable of being admixed with water in any rate or a mixed solvent of the organic solvent and water to give a polymer solution having a polymer concentration of not more than 10% by weight;
- (b) self-emulsifying the polymer solution by addition of water in an amount of not less than 80% by weight of the polymer solution to give an emulsified stock solution;
- and
- (c) removing a part of the solvents present in the emulsified stock solution to concentrate it.
A method for preparing an aqueous emulsion for coating solid pharmaceutical preparations comprising the following steps (a) to (c):
- (a) dissolving a water-insoluble cellulosic polymer in a mixed solvent comprising an organic solvent capable of being admixed with water in any rate and a water-immiscible solvent to give a polymer solution having a polymer concentration of not more than 10% by weight;
- (b) self-emulsifying the polymer solution by addition of water in an amount of not less than 80% by weight of the polymer solution to give an emulsified stock solution:
- and
- (c) removing a part of the solvents present in the emulsified stock solution to concentrate it.
Dependencies are inferred from the claim text.