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US 5,510,533 AGranted
Process for producing 3,5-difluoroaniline and derivative thereof
AssigneeSds Biotech K.K.
InventorsHiroshi Kobayashi, Masaaki Shimizu, Haruaki Ito
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Abstract
A process for production of a 3,5-difluoroaniline compound with ease is disclosed, which comprise reacting an aminating agent with a 1,3,5-trifluorobenzene compound.
Claims10
A process for producing a 3,5-difluoroaniline compound represented by formula (I) ##STR4## comprising the steps of:
- (a) decarboxylating a 2,4,6-trifluoroisophthalic acid compound of formula (III) ##STR5## to thereby obtain the 1,3,5-trifluorobenzene compound represented by formula (II) ##STR6## and (b) reacting an aminating agent with said 1,3,5-trifluorobenzene compound represented by formula (II) to produce said 3,5-difluoroaniline compound represented by formula (I);
- wherein X represents a hydrogen atom or a chlorine atom.
A process for producing a 3,5-difluoroaniline compound represented by formula (I) ##STR7## wherein X represents a hydrogen atom, comprising the steps of:
- (a) decarboxylating a 2,4,6-trifluoroisophthalic acid compound of formula (III) ##STR8## wherein X" represents a chlorine, to thereby obtain 2-chloro-1,3,5-tri-fluorobenzene;
- (b) dechlorinating said 2-chloro-1,3,5-tri-fluorobenzene to thereby obtain the 1,3,5-trifluorobenzene compound represented by formula (II) ##STR9## wherein X' represents a hydrogen atom;
- and (c) reacting an aminating agent with said 1,3,5-trifluorobenzene compound represented by formula (II) to produce said 3,5-difluoroaniline compound represented by formula (I).
Dependencies are inferred from the claim text.