Synthesis of N-formyl-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine ethyl ester and its regioselective radiofluorodestannylation to 6- .sup.18 F!fluoro-1-dopa
AssigneeThe Regents of the University of California
InventorsNagichettiar Satyamurthy, Jorge R. Barrio, Allyson J. Bishop, Mohammad Namavari, Gerald T. Bida
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Abstract
A process for forming a 6-fluoro derivative of compounds in the L-Dopa family comprising the steps of protecting the groups attached to the benzene ring in the compound followed by serially reacting the protected compound with (a) iodine and silver trifluoroacetic acid; (b) Bb.sub.3 ; (c) dit-butyldicarbonate; (d) hexamethyltin; (e) a fluoro compound; (f) hydrobromic acid; and (g) raising the pH to .ltoreq.7.
Claims3
The process of forming 6-fluoro derivatives of a benzene containing chemical compound selected from the group consisting of L-DOPA and chemicals in the L-DOPA family comprising the steps of:
- (a) in the presence of acetic anhydride, reacting the chemical compound containing a benzene ring with a second chemical compound capable of protecting a chemical moiety on the first benzene carbon,
- (b) reacting the product of step (a) with iodine and silver trifluoroacetate,
- (c) reacting the product of step (b) with BBr.sub.3,
- (d) reacting the product of step (c) with di t-butyl dicarbonate,
- (e) reacting the product of step (d) with hexamethyliditin;
- (f) bubbling an unlabelled or radiolabeled fluorine compound selected from the group consisting of .sup.18 F!CH.sub.3 COOF, .sup.18 F!F.sub.2, and .sup.18 F!OF.sub.2 and combinations thereof through the product of step (e);
- (g) treating the product of step (f) above with hydrobromic acid;
- (h) raising the pH of the product of step (g) above to a value .ltoreq.7 by the addition of NaOH.
Dependencies are inferred from the claim text.