US 5,510,520 AGranted

Optical resolution method

AssigneeKankyo Kagaku Center Co., Ltd.

InventorMasatoshi Kawashima

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Abstract

The present invention provides three optical resolution methods. The first aspect comprises the steps of adding an optically active bifunctional resolving reagent to a bifunctional compound to form a liquid material, precipitating crystals therefrom, and treating the crystals and the liquid material separately with an acidic material, a basic material, or a basic material and an acidic material, to obtain a pair of enantiomers of an optically active bifunctional compound. The second aspect comprises an optical resolution method by which one necessary enantiomer of a pair of enantiomers in an optically active bifunctional compound is exclusively obtained. The third aspect comprises a method for racemizing one unnecessary enantiomer of a pair of enantiomers in an optically active bifunctional compound which is formed by the optical resolution method of the present invention.

Claims5

Dependent claims

A method for optically resolving a bifunctional compound, which comprises the steps of:

reacting an optically active bifunctional resolving reagent with said bifunctional compound to form a liquid material,
precipitating first crystals from said liquid material,
separating said first crystals from said liquid material,
(a) treating said first crystals thus separated with an acidic material, a basic material, or both a basic material and an acidic material,
(b) heating the separated liquid material, cooling it or allowing it to stand, whereby second crystals are formed, separating said second crystals from the liquid material, and then treating the separated second crystals with an acidic material, a basic material, or both a basic material and an acidic material, and
collecting only one enantiomer of a pair of enantiomers of an optically active bifunctional compound from said steps (a) and (b),
wherein said bifunctional compound is a compound selected from the group consisting of dihydroxy compounds, hydroxyoxime compound and diamino compounds, and said optically active bifunctional resolving reagent is an optically active diamino compound or an optically active dihydroxy compound.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 08/293,036Filed 19 Aug 1994 · continuation
Priority: JP 2-2068466 Aug 1990
Granted: 23 Apr 1996
Term ends: Not estimatedThe source records don’t support an estimate.

Classification15 codes

C07B 55/00
Racemisation
C07B 57/00
Separation of optically-active compounds
C07C 29/92
By treatment giving rise to a chemical modification of at least one compound: by a consecutive conversion and reconstruction
C07C 37/00
Preparation of compounds having hydroxy or o-metal groups bound to a carbon