US 5,510,500 A · Derivatives of ryanodine and dehydroryanodine

Abstract

Novel O.sub.10eq -derivatives of ryanodine and dehydroryanodine characterized as binding strongly to ryanodine receptor, useful in affecting Ca.sup.++ efflux in tissue and also in isolating ryanodine receptor from sarcoplasmic reticulum. Also described are novel radio-iodinated alanine derivatives useful to radio label ryanodine and dehydroryanodine derivatives.

Claims3

Dependent claims

A compound of the formula ##STR6## in which R is H or a lower alkyl group.

Dependencies are inferred from the claim text.

Facts

Application

08/443,273Filed 17 May 1995 · division

Priority

18 Apr 1991

Granted

23 Apr 1996

Term ends

Not estimatedThe source records don’t support an estimate.

Classification4 codes

C07D 493/08
In which the condensed system contains two hetero rings: bridged systems
C07F 5/022
Boron compounds: without C-boron linkages
C07D
Heterocyclic compounds
C07F
Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen

Family

Serial687,712Parent of this continuation-in-part · filed 18 Apr 1991

Serial857,622Parent of this continuation-in-part · filed 25 Mar 1992

Serial25,150Parent of this division · filed 2 Mar 1993

US 5,432,288 AParent of this division

US 5,510,500 AThis patent

From the US filing history. Foreign family members aren’t listed.

Derivatives of ryanodine and dehydroryanodine

Life of this patent

Abstract

Claims3

Derivatives of ryanodine and dehydroryanodine

Life of this patent

Abstract

Claims3